"Invitae"[submitter] AND "CDH1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 371894	NM_004360.4(CDH1):c.-288del	CDH1	Deletion	not provided +1 more	GConflicting classifications of pathogenicity
Select item 12247	NM_004360.4(CDH1):c.-124-161C>A	CDH1	Single nucleotide variant	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 417390	NC_000016.10:g.(?_68737292)_(68738411_?)del	LOC130059290, CDH1	Deletion	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 417388	NC_000016.10:g.(?_68737292)_(68835541_?)del	LOC130059296, LOC130059297 +24 more	Deletion	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 239871	NM_004360.4(CDH1):c.-124-?_*2042+?dup4815	LOC112486201, LOC128772402 +24 more	Duplication	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 221174	NM_004360.5(CDH1):c.-71C>G	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 221181	NM_004360.5(CDH1):c.-54G>C	LOC130059290, CDH1	Single nucleotide variant (5 prime UTR variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 239872	NM_004360.5(CDH1):c.-49G>T	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 653530	NC_000016.10:g.(?_68737406)_(68833509_?)del	CDH1, LOC112486201 +24 more	Deletion	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 646954	NC_000016.9:g.(?_68771309)_(68772324_?)dup	CDH1, LOC130059290	Duplication	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 584183	NC_000016.9:g.(?_68771309)_(68867412_?)dup	CDH1, LOC112486201 +24 more	Duplication	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 583823	NC_000016.10:g.(?_68737406)_(68738421_?)del	CDH1, LOC130059290	Deletion	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 463684	NC_000016.9:g.(?_68771313)_(68772320_?)dup	CDH1	Duplication	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 2035285	NM_004360.5(CDH1):c.1A>T (p.Met1Leu)	CDH1 (M1L)	Single nucleotide variant (missense variant +2 more)	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 532457	NM_004360.5(CDH1):c.1A>G (p.Met1Val)	CDH1 (M1V)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 532474	NM_004360.5(CDH1):c.2T>G (p.Met1Arg)	CDH1 (M1R)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 486826	NM_004360.5(CDH1):c.2T>C (p.Met1Thr)	CDH1 (M1T)	Single nucleotide variant (5 prime UTR variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 239906	NM_004360.5(CDH1):c.3G>A (p.Met1Ile)	CDH1 (M1I)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 2826614	NM_004360.5(CDH1):c.4G>C (p.Gly2Arg)	CDH1 (G2R)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 183998	NM_004360.5(CDH1):c.4G>A (p.Gly2Ser)	CDH1 (G2S)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 239909	NM_004360.5(CDH1):c.5G>T (p.Gly2Val)	CDH1 (G2V)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 184107	NM_004360.5(CDH1):c.6C>T (p.Gly2=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 418111	NM_004360.5(CDH1):c.7C>T (p.Pro3Ser)	CDH1 (P3S)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 142469	NM_004360.5(CDH1):c.8C>G (p.Pro3Arg)	CDH1 (P3R)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 463799	NM_004360.5(CDH1):c.9T>C (p.Pro3=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 1719790	NM_004360.5(CDH1):c.10T>G (p.Trp4Gly)	CDH1 (W4G)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 918853	NM_004360.5(CDH1):c.11G>A (p.Trp4Ter)	CDH1 (W4*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 463713	NM_004360.5(CDH1):c.13A>G (p.Ser5Gly)	CDH1 (S5G)	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 855406	NM_004360.5(CDH1):c.14G>A (p.Ser5Asn)	CDH1 (S5N)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 184111	NM_004360.5(CDH1):c.15C>T (p.Ser5=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 1349815	NM_004360.5(CDH1):c.16C>A (p.Arg6Ser)	CDH1 (R6S)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 1040439	NM_004360.5(CDH1):c.17G>T (p.Arg6Leu)	CDH1 (R6L)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 1556744	NM_004360.5(CDH1):c.18C>T (p.Arg6=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 820715	NM_004360.5(CDH1):c.20G>C (p.Ser7Thr)	CDH1 (S7T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 463745	NM_004360.5(CDH1):c.21C>T (p.Ser7=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 1410393	NM_004360.5(CDH1):c.22C>T (p.Leu8Phe)	CDH1 (L8F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 821055	NM_004360.5(CDH1):c.22C>G (p.Leu8Val)	CDH1 (L8V)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 630530	NM_004360.5(CDH1):c.24C>G (p.Leu8=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related condition +2 more	GLikely benign
Select item 382251	NM_004360.5(CDH1):c.24C>T (p.Leu8=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	not specified +1 more	GLikely benign
Select item 532470	NM_004360.5(CDH1):c.25T>G (p.Ser9Ala)	CDH1 (S9A)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 2703400	NM_004360.5(CDH1):c.26C>G (p.Ser9Trp)	CDH1 (S9W)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 651982	NM_004360.5(CDH1):c.26C>A (p.Ser9Ter)	CDH1 (S9*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 479485	NM_004360.5(CDH1):c.26C>T (p.Ser9Leu)	CDH1 (S9L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 479527	NM_004360.5(CDH1):c.27G>C (p.Ser9=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 184065	NM_004360.5(CDH1):c.27G>A (p.Ser9=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related condition +4 more	GConflicting classifications of pathogenicity
Select item 649532	NM_004360.5(CDH1):c.28G>A (p.Ala10Thr)	CDH1 (A10T)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 968651	NM_004360.5(CDH1):c.29delinsGGCT (p.Ala10delinsGlyLeu)	CDH1	Indel (inframe_indel +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 584912	NM_004360.5(CDH1):c.29C>A (p.Ala10Glu)	CDH1 (A10E)	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 532451	NM_004360.5(CDH1):c.29C>T (p.Ala10Val)	CDH1 (A10V)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 220798	NM_004360.5(CDH1):c.32TGC[6] (p.Leu15dup)	CDH1	Microsatellite (inframe_insertion +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 142455	NM_004360.5(CDH1):c.32TGC[7] (p.Leu14_Leu15dup)	CDH1	Microsatellite (inframe_insertion +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 2109820	NM_004360.5(CDH1):c.30G>A (p.Ala10=)	CDH1	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 803264	NM_004360.5(CDH1):c.32TGC[4] (p.Leu15del)	CDH1 (L15del)	Microsatellite (inframe_deletion +1 more)	Hereditary diffuse gastric adenocarcinoma	GConflicting classifications of pathogenicity
Select item 628358	NM_004360.5(CDH1):c.32TGC[2] (p.Leu13_Leu15del)	CDH1	Microsatellite (inframe_deletion +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 491533	NM_004360.5(CDH1):c.30G>T (p.Ala10=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 1459167	NM_004360.5(CDH1):c.31del (p.Leu11fs)	CDH1 (L11fs)	Deletion (frameshift variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 1132551	NM_004360.5(CDH1):c.31C>T (p.Leu11=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 1022673	NM_004360.5(CDH1):c.32T>C (p.Leu11Pro)	CDH1 (L11P)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 584913	NM_004360.5(CDH1):c.32T>G (p.Leu11Arg)	CDH1 (L11R)	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 182377	NM_004360.5(CDH1):c.33G>C (p.Leu11=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 414047	NM_004360.5(CDH1):c.34C>T (p.Leu12=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1485142	NM_004360.5(CDH1):c.35T>C (p.Leu12Pro)	CDH1 (L12P)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 2583748	NM_004360.5(CDH1):c.42dup (p.Leu15fs)	CDH1 (L15fs)	Duplication (frameshift variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 576714	NM_004360.5(CDH1):c.44T>A (p.Leu15Gln)	CDH1 (L15Q)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 919859	NM_004360.5(CDH1):c.45G>A (p.Leu15=)	CDH1	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GLikely benign
Select item 2583204	NM_004360.5(CDH1):c.46C>T (p.Gln16Ter)	CDH1 (Q16*)	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 1997167	NM_004360.5(CDH1):c.46C>G (p.Gln16Glu)	CDH1 (Q16E)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 2128748	NM_004360.5(CDH1):c.47A>G (p.Gln16Arg)	CDH1 (Q16R)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 628144	NM_004360.5(CDH1):c.47A>T (p.Gln16Leu)	CDH1 (Q16L)	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1040346	NM_004360.5(CDH1):c.48G>C (p.Gln16His)	CDH1 (Q16H)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 574809	NM_004360.5(CDH1):c.48G>A (p.Gln16=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GConflicting classifications of pathogenicity
Select item 406629	NM_004360.5(CDH1):c.48G>T (p.Gln16His)	CDH1 (Q16H)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma	GUncertain significance
Select item 2710949	NM_004360.5(CDH1):c.48+1G>C	CDH1	Single nucleotide variant (splice donor variant)	Hereditary diffuse gastric adenocarcinoma	GPathogenic
Select item 491543	NM_004360.5(CDH1):c.48+5C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 491542	NM_004360.5(CDH1):c.48+5_48+6delinsGT	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 491541	NM_004360.5(CDH1):c.48+5_48+6delinsAT	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 491540	NM_004360.5(CDH1):c.48+5_48+6delinsTT	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 140784	NM_004360.5(CDH1):c.48+5C>G	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 922365	NM_004360.5(CDH1):c.48+6_48+7delinsTG	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 136692	NM_004360.5(CDH1):c.48+6C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 136068	NM_004360.3(CDH1):c.48+6_48+7delinsTT	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 1587108	NM_004360.5(CDH1):c.48+7C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 2172705	NM_004360.5(CDH1):c.48+8G>A	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 1151312	NM_004360.5(CDH1):c.48+8G>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 1091938	NM_004360.5(CDH1):c.48+10A>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 381238	NM_004360.5(CDH1):c.48+10A>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 491539	NM_004360.5(CDH1):c.48+12C>A	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 379282	NM_004360.5(CDH1):c.48+13C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 1660287	NM_004360.5(CDH1):c.48+14C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 2835116	NM_004360.5(CDH1):c.48+15C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 182378	NM_004360.5(CDH1):c.48+15_48+16del	CDH1	Deletion (intron variant)	Familial cancer of breast +6 more	GBenign/Likely benign
Select item 2037759	NM_004360.5(CDH1):c.48+16T>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 142330	NM_004360.5(CDH1):c.48+16T>C	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 2726325	NM_004360.5(CDH1):c.48+17G>A	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 1261685	NM_004360.5(CDH1):c.48+19C>T	CDH1	Single nucleotide variant (intron variant)	not provided +1 more	GBenign/Likely benign
Select item 391234	NM_004360.5(CDH1):c.49-20C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 491545	NM_004360.5(CDH1):c.49-19T>C	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 2732667	NM_004360.5(CDH1):c.49-17C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 2796242	NM_004360.5(CDH1):c.49-16C>A	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 2738304	NM_004360.5(CDH1):c.49-16_49-15insA	CDH1	Insertion (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign

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